Cancer Stem Cell - Revision history

Jfromm at 18:52, 7 October 2009

2009-10-07T18:52:20Z

← Older revision		Revision as of 13:52, 7 October 2009
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	'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) which resemble healthy stem cells. They possess characteristics associated with normal stem cells. These tumour-initiating cells are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear. Recent research showed that some cancer stem cells are governed by the same regulatory pathways as their healthy stem cell counterparts [http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html]. The ability of self-renewal is one of the reasons why they're hard to treat.		'''Cancer stem cells''' (CSCs) are [[Cancer\|cancer]] cells (found within tumors or cancers) which resemble healthy stem cells. They possess characteristics associated with normal stem cells. These tumour-initiating cells are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear. Recent research showed that some cancer stem cells are governed by the same regulatory pathways as their healthy stem cell counterparts [http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html]. The ability of self-renewal is one of the reasons why they're hard to treat.

	Like queen bees in a bee hive, cancer stem cells are constantly replenishing their "hive" of tumor cells. Therapies that kill off the workers may reduce the size of the tumor, but will ultimately be unsuccessful unless they also eliminate the stem cells working behind the scenes. They will suppress the symptoms of the disease, but won't kill the root cause.		Like queen bees in a bee hive, cancer stem cells are constantly replenishing their "hive" of tumor cells. Therapies that kill off the workers may reduce the size of the tumor, but will ultimately be unsuccessful unless they also eliminate the stem cells working behind the scenes. They will suppress the symptoms of the disease, but won't kill the root cause.

Jfromm at 17:49, 26 September 2009

2009-09-26T17:49:16Z

← Older revision		Revision as of 12:49, 26 September 2009
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	'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) ~~that~~ possess characteristics associated with normal stem cells. ~~They~~ are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.		'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) which resemble healthy stem cells. They possess characteristics associated with normal stem cells. These tumour-initiating cells are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear. Recent research showed that some cancer stem cells are governed by the same regulatory pathways as their healthy stem cell counterparts [http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html]. The ability of self-renewal is one of the reasons why they're hard to treat.

	Like queen bees in a bee hive, cancer stem cells are constantly replenishing their "hive" of tumor cells. Therapies that kill off the workers may reduce the size of the tumor, but will ultimately be unsuccessful unless they also eliminate the stem cells working behind the scenes. They will suppress the symptoms of the disease, but won't kill the root cause.		Like queen bees in a bee hive, cancer stem cells are constantly replenishing their "hive" of tumor cells. Therapies that kill off the workers may reduce the size of the tumor, but will ultimately be unsuccessful unless they also eliminate the stem cells working behind the scenes. They will suppress the symptoms of the disease, but won't kill the root cause.
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	* New York Times: [http://www.nytimes.com/2006/02/21/health/21canc.html Stem Cells May Be Key to Cancer]		* New York Times: [http://www.nytimes.com/2006/02/21/health/21canc.html Stem Cells May Be Key to Cancer]

			* Nature [http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html Cancer stem cells resemble healthy stem cells, resist chemotherapy]

	[[Category:Cancer]]		[[Category:Cancer]]

Jfromm at 22:06, 27 August 2009

2009-08-27T22:06:42Z

← Older revision		Revision as of 17:06, 27 August 2009
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	'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.		'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.

			Like queen bees in a bee hive, cancer stem cells are constantly replenishing their "hive" of tumor cells. Therapies that kill off the workers may reduce the size of the tumor, but will ultimately be unsuccessful unless they also eliminate the stem cells working behind the scenes. They will suppress the symptoms of the disease, but won't kill the root cause.

	== Links ==		== Links ==

Jfromm at 22:01, 27 August 2009

2009-08-27T22:01:51Z

← Older revision		Revision as of 17:01, 27 August 2009
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	* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]		* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]

	* [http://www.economist.com/opinion/displaystory.cfm?story_id=12202589 Cancer stem cells: The root of all evil?]		* The Economist: [http://www.economist.com/opinion/displaystory.cfm?story_id=12202589 Cancer stem cells: The root of all evil?]

			* New York Times: [http://www.nytimes.com/2006/02/21/health/21canc.html Stem Cells May Be Key to Cancer]

	[[Category:Cancer]]		[[Category:Cancer]]

Jfromm at 21:40, 27 August 2009

2009-08-27T21:40:16Z

← Older revision		Revision as of 16:40, 27 August 2009
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	* [http://www.economist.com/opinion/displaystory.cfm?story_id=12202589 Cancer stem cells: The root of all evil?]		* [http://www.economist.com/opinion/displaystory.cfm?story_id=12202589 Cancer stem cells: The root of all evil?]

			[[Category:Cancer]]

Jfromm at 21:15, 27 August 2009

2009-08-27T21:15:33Z

← Older revision		Revision as of 16:15, 27 August 2009
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	* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]		* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]

			* [http://www.economist.com/opinion/displaystory.cfm?story_id=12202589 Cancer stem cells: The root of all evil?]

Jfromm at 14:37, 15 February 2009

2009-02-15T14:37:06Z

← Older revision		Revision as of 09:37, 15 February 2009
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	'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.		'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. Both properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.

	== Links ==		== Links ==

Jfromm at 14:33, 15 February 2009

2009-02-15T14:33:06Z

← Older revision		Revision as of 09:33, 15 February 2009
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	== Links ==		== Links ==

	* ~~[Cancer Stem Cell–Directed Therapies:~~ Recent Data From the Laboratory and Clinic http://www.nature.com/mt/journal/v17/n2/full/mt2008254a.html]		* Recent Data From the Laboratory and Clinic about [http://www.nature.com/mt/journal/v17/n2/full/mt2008254a.html Cancer Stem Cell–Directed Therapies]

	* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]		* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]

Jfromm: New page: '''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fu...

2009-02-15T14:32:35Z

New page: '''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fu...

New page

'''Cancer stem cells''' (CSCs) are cancer cells (found within tumors or cancers) that possess characteristics associated with normal stem cells. They are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted, and (ii) self-renew. If treatments of cancer do not properly destroy enough CSCs, the tumor will reappear.

== Links ==

* [Cancer Stem Cell–Directed Therapies: Recent Data From the Laboratory and Clinic http://www.nature.com/mt/journal/v17/n2/full/mt2008254a.html]

* Wikipedia Entry for [http://en.wikipedia.org/wiki/Cancer_stem_cell Cancer Stem Stell]